| Property |
Value |
| Working Groups |
RG Ehrenreich, 
RG Nave, 
RG Simons |
| Subproject |
C01 |
| Open Access |
Yes |
| Publication Type |
Journal Article |
| Peer Reviewed |
Yes |
| PMID |
37258678 |
| DOI |
10.1038/s41586-023-06120-6 |
| Publication Year |
2023 |
| Title |
Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease |
| Journal |
Nature |
| ISSN |
0028-0836 |
| eISSN |
1476-4687 |
| URL |
http://dx.doi.org/10.1038/s41586-023-06120-6 |
| Journal Abbreviation |
Nature |
| Authors |
Depp C, Sun T, Sasmita AO, Spieth L, Berghoff SA, Nazarenko T, Overhoff K, Steixner-Kumar AA, Subramanian S, Arinrad S, Ruhwedel T, Möbius W, Göbbels S, Saher G, Werner HB, Damkou A, Zampar S, Wirths O, Thalmann M, Simons M, Saito T, Saido T, Krueger-Burg D, Kawaguchi R, Willem M, Haass C, Geschwind D, Ehrenreich H, Stassart R, Nave K |
| First Author |
Depp C |
| Last Author |
Nave K |
External Resources
nature.c...stickyhttps://www.nature.com/articles/s41586-023-06120-6.pdf?pdf=button%20sticky Article fulltext
GSE178304https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE178304 NCBI GEO Dataset (GSE178304)
GSE178296https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE178296 NCBI GEO Dataset (GSE178296)
GSE208683https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE208683 NCBI GEO Dataset (GSE208683)
GSE178295https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE178295 NCBI GEO Dataset (GSE178295)
0000-0003-2868-6932https://orcid.org/0000-0003-2868-6932 ORCID identifier (Constanze Depp)
0000-0002-7104-7215https://orcid.org/0000-0002-7104-7215 ORCID identifier (Ting Sun)
0000-0002-0308-0144https://orcid.org/0000-0002-0308-0144 ORCID identifier (Lena Spieth)
0000-0001-7913-2716https://orcid.org/0000-0001-7913-2716 ORCID identifier (Agnes A. Steixner-Kumar)
0000-0002-9535-9395https://orcid.org/0000-0002-9535-9395 ORCID identifier (Torben Ruhwedel)
0000-0002-2902-7165https://orcid.org/0000-0002-2902-7165 ORCID identifier (Wiebke Möbius)
0000-0003-3507-9604https://orcid.org/0000-0003-3507-9604 ORCID identifier (Gesine Saher)
0000-0002-7710-5738https://orcid.org/0000-0002-7710-5738 ORCID identifier (Hauke B. Werner)
0000-0002-5082-0790https://orcid.org/0000-0002-5082-0790 ORCID identifier (Alkmini Damkou)
0000-0003-0134-0974https://orcid.org/0000-0003-0134-0974 ORCID identifier (Silvia Zampar)
0000-0002-4115-0334https://orcid.org/0000-0002-4115-0334 ORCID identifier (Oliver Wirths)
0000-0002-0610-210Xhttps://orcid.org/0000-0002-0610-210X ORCID identifier (Maik Thalmann)
0000-0001-5329-192Xhttps://orcid.org/0000-0001-5329-192X ORCID identifier (Mikael Jakob Simons)
0000-0003-1970-6903https://orcid.org/0000-0003-1970-6903 ORCID identifier (Takaomi Saido)
0000-0001-5597-6287https://orcid.org/0000-0001-5597-6287 ORCID identifier (Dilja Krueger-Burg)
0000-0002-4869-1627https://orcid.org/0000-0002-4869-1627 ORCID identifier (Christian Haass)
0000-0003-2896-3450https://orcid.org/0000-0003-2896-3450 ORCID identifier (Daniel Geschwind)
0000-0001-8371-5711https://orcid.org/0000-0001-8371-5711 ORCID identifier (Hannelore Maria Ehrenreich)
0000-0001-8724-9666https://orcid.org/0000-0001-8724-9666 ORCID identifier (Klaus-Armin Nave)
2/61https://rdp.sfb274.de/archive/2/61 Research Data Archive (supplemental material)
043j0f473https://ror.org/043j0f473 ROR identifier (043j0f473, German Center for Neurodegenerative Diseases)
03av75f26https://ror.org/03av75f26 ROR identifier (03av75f26, Max Planck Institute for Multidisciplinary Sciences)
025z3z560https://ror.org/025z3z560 ROR identifier (025z3z560, Munich Cluster for Systems Neurology)
02kkvpp62https://ror.org/02kkvpp62 ROR identifier (02kkvpp62, Technical University of Munich)
SCR_018000https://scicrunch.org/resolver/SCR_018000 SciCrunch identifier (RRID:SCR_018000, arivis Vision4D)
SCR_017344https://scicrunch.org/resolver/SCR_017344 SciCrunch identifier (RRID:SCR_017344, Cell Ranger)
SCR_015687https://scicrunch.org/resolver/SCR_015687 SciCrunch identifier (RRID:SCR_015687, DESeq2)
SCR_014583https://scicrunch.org/resolver/SCR_014583 SciCrunch identifier (RRID:SCR_014583, FastQC)
SCR_012919https://scicrunch.org/resolver/SCR_012919 SciCrunch identifier (RRID:SCR_012919, featureCounts)
SCR_002285https://scicrunch.org/resolver/SCR_002285 SciCrunch identifier (RRID:SCR_002285, Fiji)
SCR_002798https://scicrunch.org/resolver/SCR_002798 SciCrunch identifier (RRID:SCR_002798, GraphPad Prism)
SCR_018863https://scicrunch.org/resolver/SCR_018863 SciCrunch identifier (RRID:SCR_018863, Imspector)
SCR_016340https://scicrunch.org/resolver/SCR_016340 SciCrunch identifier (RRID:SCR_016340, MAST)
SCR_007322https://scicrunch.org/resolver/SCR_007322 SciCrunch identifier (RRID:SCR_007322, Seurat)
SCR_015899https://scicrunch.org/resolver/SCR_015899 SciCrunch identifier (RRID:SCR_015899, STAR)
SCR_005223https://scicrunch.org/resolver/SCR_005223 SciCrunch identifier (RRID:SCR_005223, STRING)
SCR_018217https://scicrunch.org/resolver/SCR_018217 SciCrunch identifier (RRID:SCR_018217, UMAP)
SCR_013672https://scicrunch.org/resolver/SCR_013672 SciCrunch identifier (RRID:SCR_013672, ZEN Digital Imaging for Light Microscopy)
static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41586-023-06120-6/MediaObjects/41586_2023_6120_MOESM1_ESM.pdf Supplemental material
github.c...nt.githttps://github.com/TSun-tech/AD_MyelinMutant.git Supplemental material (code)
goeseek.gwdguser.de/studies/31https://goeseek.gwdguser.de/studies/31 Supplemental material (goeseek study)
static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41586-023-06120-6/MediaObjects/41586_2023_6120_MOESM2_ESM.pdf Supplemental material (reporting summary)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41586-023-06120-6/MediaObjects/41586_2023_6120_MOESM3_ESM.xlsx Supplemental material (table)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41586-023-06120-6/MediaObjects/41586_2023_6120_MOESM4_ESM.xlsx Supplemental material (table)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41586-023-06120-6/MediaObjects/41586_2023_6120_MOESM5_ESM.xlsx Supplemental material (source data)
Linked Antibodies
| PID |
AG |
Type |
Antigen symbol |
Antibody Registry ID |
Name |
| primary-0039 |
 |
primary |
APP |
AB_94882 |
Anti-APP A4 Antibody |
| primary-0082 |
|
primary |
Iba1 |
AB_839504 |
Anti Iba1, Rabbit (for Immunocytochemistry) |
| primary-0083 |
|
primary |
|
AB_2564653 |
Purified anti-β-Amyloid, 1-16 Antibody (Previously Covance catalog# SIG-39320) |
| primary-0084 |
|
primary |
CNP |
AB_2665789 |
Monoclonal Anti-CNP Antibody |
| primary-0085 |
|
primary |
BACE1 |
|
Recombinant Anti-BACE1 antibody [EPR19523] (ab183612) |
| primary-0086 |
|
primary |
GFAP |
AB_563739 |
Anti-Glial Fibrillary Acidic Protein Monoclonal Antibody, Unconjugated |
| primary-0087 |
|
primary |
APP |
AB_258409 |
Anti-Amyloid Precursor Protein, C-Terminal antibody produced in rabbit |
| primary-0088 |
|
primary |
APP |
AB_2056967 |
APP antibody |
| primary-0089 |
|
primary |
APP |
AB_2798041 |
β-Amyloid (1-42) (D3E10) Rabbit mAb |
| primary-0090 |
|
primary |
ApoE |
AB_2798191 |
ApoE (pan) (D7I9N) Rabbit mAb |
| primary-0091 |
|
primary |
PSN2 |
AB_882202 |
Recombinant Anti-Presenilin 2/AD5 antibody [EP1515Y] |
| primary-0096 |
|
primary |
BACE1 |
AB_1903900 |
BACE1 (D10E5) Rabbit mAb |
| primary-0097 |
|
primary |
TREM2 |
AB_2799888 |
TREM2 (E7P8J) Rabbit mAb (Carboxy-terminal Antigen) |
| secondary-0015 |
 |
secondary |
|
AB_2535849 |
Goat anti-Rabbit IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor 555 |
| secondary-0019 |
|
secondary |
|
AB_2535844 |
Goat anti-Mouse IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor 555 |
| secondary-0092 |
|
secondary |
|
AB_1307538 |
Goat anti-Mouse IgG (H+L) Secondary Antibody, DyLight™ 633 |
| secondary-0093 |
|
secondary |
|
AB_162543 |
Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor 555 |
| secondary-0094 |
|
secondary |
|
AB_1965953 |
Goat anti-Rabbit IgG (H+L) Cross-Adsorbed Secondary Antibody, DyLight™ 633 |
| secondary-0095 |
|
secondary |
|
AB_844397 |
Goat anti-Mouse IgG (H+L) Secondary Antibody, DyLight™ 488 |
| secondary-0098 |
|
secondary |
|
AB_2556616 |
Goat anti-Rabbit IgG (H+L) Cross-Adsorbed Secondary Antibody, DyLight™ 800 |
| secondary-0099 |
|
secondary |
|
AB_614942 |
Goat anti-Mouse IgG (H+L) Secondary Antibody, DyLight™ 680 |
Linked Mouselines